This study analyzed the influence of stage at breast cancer diagnosis, tumor biology, and treatment on survival with contemporary times of better systemic therapy. The participants in the study were female patients with primary breast cancer diagnosed between 1999-2005 and 2006-2012. The main outcomes were that patients from the more recent cohort (2006-2012) had smaller and more often lymph node-negative tumors and they received more chemotherapy, hormonal therapy, and targeted therapy. Overall, improvements in screening in treatment leads to better mortality rates for women with breast cancer.